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Description

What Is Ashwagandha Root Extract?
Ashwagandha (Withania somnifera) root extract is one of the most researched natural adaptogen supplements in modern clinical science. Used for over 6,000 years in Ayurvedic medicine as a tonic for stress, vitality, and longevity, the root contains naturally occurring withanolides — bioactive steroidal lactones that drive its adaptogenic effects by regulating the HPA axis and normalizing cortisol output. Unlike stimulants, ashwagandha root works by restoring the body's own stress regulation mechanisms rather than forcing a response. Remedy's Nutrition® delivers 1,000 mg of pure root extract per vegan capsule; for the full science, dosing, and history, see our complete guide to ashwagandha.

Supplement Facts
Serving size: 1 Vegan Capsule. Servings per container: 60.



Amount Per Serving
Amount
% Daily Value



Ashwagandha (Withania somnifera)
1000 mg
*




* Daily Value not established.
Other ingredients: Cellulose, Glycerin, Water (vegan capsule)
Directions: One capsule daily.
Non-GMO, vegan, gluten free, no additives, no preservatives. Made in the USA.



Ashwagandha Benefits: Clinical Evidence Summary




Benefit Area
Key Clinical Finding
Dose Used in Trial



Stress & Cortisol[1]Ashwagandha for Stress and Anxiety Reduction RCT — Indian Journal of Psychological Medicine View source
Serum cortisol reduced 27.9%; perceived stress scores improved significantly vs placebo
300 mg twice daily, 60 days


Anxiety Relief
Anxiety scores (HAM-A) reduced 56.5% vs 30.5% in placebo — 8-week double-blind RCT
300 mg twice daily


Sleep Quality
Sleep onset latency improved; total sleep time +72 min vs placebo in 8-week trial
300 mg twice daily


Testosterone (Men)
Testosterone increased 10–22% in stressed and subfertile males vs controls
300–675 mg daily, 8–90 days


Muscle Strength
Bench press 1RM +46 kg vs +26 kg placebo; greater arm muscle size gains by MRI
300 mg twice daily, 8 weeks


Cognitive Function
Reaction time, task accuracy, and memory improved vs placebo at 8 weeks
300 mg twice daily


Thyroid Support
T3 and T4 significantly elevated in subclinical hypothyroid patients vs placebo
600 mg daily, 8 weeks


Immune Function
NK cell and T-cell activity enhanced; immunoglobulin levels increased vs baseline
6 mg/kg daily, 96 days






Natural stress and anxiety relief through cortisol and GABA regulation
Restful sleep and faster sleep onset — especially for stress-related insomnia
Healthy testosterone and hormone balance in men and women
Muscle strength, endurance, and faster recovery from training
Cognitive function, focus, and mental clarity under stress
Thyroid and adrenal gland support
Immune system support via withanolide activity
Blood sugar balance and healthy inflammation response













Ashwagandha for Anxiety and Stress: How It Works
Ashwagandha is one of the few natural anxiety supplements with multiple randomized controlled trials supporting its efficacy. It works through 2 complementary pathways: HPA axis regulation (reducing excess cortisol) and GABA receptor modulation (promoting calm without sedation). This dual mechanism distinguishes it from single-pathway interventions like magnesium or L-theanine.




Pathway
Mechanism
Outcome



HPA Axis
Withanolides suppress excess cortisol secretion from the adrenal glands
Lower perceived stress, reduced burnout symptoms, improved resilience


GABA Receptors
Withanolide A acts as a GABA-A receptor modulator, similar to how benzodiazepines work — but without dependency risk
Reduced anxiety, calmer baseline mood, easier sleep onset


Sympathetic Tone
Reduces excess sympathetic nervous system activation (the "fight or flight" state)
Lower resting heart rate, reduced anxiety-related physical symptoms





In a double-blind RCT (Chandrasekhar et al., 2012), 300 mg twice daily for 60 days reduced HAM-A anxiety scores by 56.5% compared to 30.5% in the placebo group. Natural stress relief and anxiety management are the most consistently replicated benefits across the ashwagandha literature[2]Ashwagandha Stress-Relieving Pharmacological Actions Trial — Medicine (Baltimore) View source.












Ashwagandha for Women: Hormones, Sleep, and Stress
Ashwagandha benefits women across several key areas — hormonal balance, stress resilience, sleep quality, and thyroid function. Women with chronic stress show elevated cortisol which disrupts estrogen and progesterone balance, impairs sleep, and contributes to fatigue. As a natural adaptogen, ashwagandha root normalizes this cortisol excess, creating downstream improvements in hormonal balance without directly affecting sex hormones.




Area
What the Evidence Shows
Who Benefits Most



Stress & Mood
Cortisol reduction and mood score improvements in trials including women
Women with high-stress lifestyles, burnout


Sleep Quality
Sleep onset and duration improved — particularly in stress-related insomnia
Women with anxiety-driven poor sleep


Thyroid Support
T3 and T4 elevated in subclinical hypothyroid patients (condition more prevalent in women)
Women with subclinical hypothyroidism


Sexual Function
A 2015 RCT showed improved arousal, lubrication, and satisfaction vs placebo in healthy women
Women experiencing stress-related low libido


Menopause
Emerging data suggests cortisol normalization may ease menopause-related mood and sleep disruption
Perimenopausal and menopausal women





Important: Ashwagandha should not be taken during pregnancy — it is traditionally contraindicated and modern evidence supports this caution. Women taking thyroid medication or hormone therapy should consult their physician before use.












Why Choose Remedy's Nutrition® Ashwagandha Root?




What You Get
Why It Matters



1,000 mg pure root extract per capsule
Matches or exceeds doses used in clinical stress, sleep, and performance trials


Whole ashwagandha[3]Ashwagandha Health Information — National Center for Complementary and Integrative Health View source root — naturally occurring withanolides
Traditional Ayurvedic preparation uses the whole root, not isolated fractions. Full spectrum of active compounds preserved.


Zero fillers, binders, or additives
Many ashwagandha supplements add magnesium stearate, silicon dioxide, or rice flour. Ours contain nothing but the root.


60 vegan capsules — 2-month supply
Enough for a full clinical-length trial (8 weeks minimum to see measurable benefits)


Non-GMO, cold pressed, allergen-free
No gluten, yeast, corn, or dairy. Cold pressing preserves heat-sensitive withanolides.


Handmade in Key Largo, FL — pharmacist reviewed
Made in the USA, pharmacist-approved, quality and potency guaranteed













Ashwagandha Dosage: How to Take It
Take Remedy's Nutrition® Ashwagandha root capsules with food. No binders or fillers means better absorption and digestive tolerance compared to inferior formulas.




Goal
Suggested Dose
Timing
Minimum Duration



Stress & anxiety relief
1 capsule (1,000 mg) daily
Morning with food
4–8 weeks


Sleep support
1 capsule (1,000 mg) daily
Evening with food
4–8 weeks


Hormonal balance (women)
1 capsule (1,000 mg) daily
Morning or evening with food
8–12 weeks


Testosterone & physical performance
1–2 capsules daily
With meals during training days
8 weeks minimum


Maximum studied dose
2 capsules (2,000 mg) daily
Split: morning + evening
Up to 12 weeks





Feel free to contact us for a personalized recommendation.









Safety and Side Effects
Ashwagandha root extract is well-tolerated at standard doses. Clinical trials at 300–1,000 mg daily report side-effect rates comparable to placebo. Higher doses and extended use require more attention to the considerations below.




Consideration
Details



Common side effects
Mild GI upset, loose stools — most common on an empty stomach. Take with food to eliminate for most users.


Liver safety — hepatotoxicity signal
A 2020 Liver International case series documented 10 cases of ashwagandha-induced liver injury (5 Iceland + 5 US DILIN). LiverTox now rates hepatotoxicity as "Probable". Stop immediately and seek care for jaundice, dark urine, pale stools, right-upper-quadrant pain, or unexplained fatigue. If using above 600 mg/day or longer than 8 weeks, request a baseline ALT/AST/bilirubin panel plus a follow-up at 8–12 weeks.


Hashimoto's / autoimmune thyroid
Do not start ashwagandha without endocrinology input. The immune-modulating activity can worsen autoimmune flares, and the TSH-lowering effect can push levothyroxine users above the therapeutic range. Monitor TSH/free T4 at baseline and 6–8 weeks.


Sedatives, benzodiazepines, antipsychotics
Ashwagandha has GABAergic activity and may potentiate CNS-depressant medications — benzodiazepines (lorazepam, alprazolam, clonazepam), Z-drugs (zolpidem), antipsychotics (quetiapine), and prescription sleep medications. Do not combine without medical supervision.


Hepatotoxic drugs
Additive liver injury risk when combined with acetaminophen above 3 g/day, statins, isoniazid, antifungals, or heavy alcohol use. Use with caution and monitor LFTs.


Pregnancy — absolute contraindication

Do not use. Ashwagandha is contraindicated in all 3 trimesters of pregnancy. Traditional Ayurvedic texts list it as an abortifacient, and LiverTox / NIH guidance advises absolute avoidance. Women trying to conceive should also discontinue daily use until pregnancy status is confirmed with their clinician.


Thyroid medication
Ashwagandha root may raise T3 and T4. Monitor thyroid levels if you take levothyroxine or other thyroid drugs.


Blood sugar medications
May enhance blood sugar-lowering effects of diabetes medications. Monitor glucose levels and consult your physician.


Blood pressure medications
May have additive blood pressure-lowering effects. Consult your doctor if taking antihypertensives.


Pre-surgery
Discontinue 2 weeks before any scheduled surgery due to potential interactions with anesthesia and blood sugar control.





If you are pregnant, nursing, have a thyroid condition, or take any prescription medications, consult your physician before use.





Remedy's Nutrition® Ashwagandha Is Often Taken With:


Remedy's Nutrition® Calm Surfer® — stress and anxiety support stack

Remedy's Nutrition® GABA Calm® — enhanced calming and sleep support

Remedy's Nutrition® Magnesium Glycinate — magnesium + ashwagandha is a common sleep protocol
Remedy's Nutrition® Ultimate Multi-Mineral®
Remedy's Nutrition® Mega VMT® Multivitamin

Remedy's Nutrition® Power Surfer® — endurance and performance stack
Remedy's Nutrition® Myelin Sheath Assist®
Remedy's Nutrition® Super Diabe®


Frequently Asked Questions



What is ashwagandha root extract and how does it work? +
Ashwagandha root extract is a natural adaptogen derived from Withania somnifera root. It contains withanolides — bioactive compounds that regulate the HPA axis to reduce excess cortisol and modulate GABA receptors to promote calm. This dual mechanism supports stress relief, better sleep, and hormonal balance without stimulants or sedatives.



Does ashwagandha help with anxiety? +
Yes — multiple double-blind RCTs confirm ashwagandha reduces anxiety. One 60-day trial showed a 56.5% reduction in HAM-A anxiety scores vs 30.5% for placebo at 300 mg twice daily. The mechanism involves both cortisol reduction (HPA axis) and GABA receptor modulation. Benefits are typically noticeable within 2–4 weeks of consistent use.



Is ashwagandha good for women? +
Yes. Ashwagandha supports stress relief, sleep quality, thyroid function, and hormonal balance — all areas relevant to women's health. A 2015 RCT showed improved sexual function in healthy women. Women with subclinical hypothyroidism may benefit from thyroid hormone normalization. Avoid during pregnancy and consult your doctor if taking thyroid or hormone medications.



How long does it take for ashwagandha to work? +
Stress and sleep improvements are often noticeable within 2–4 weeks. Most clinical trials measure primary outcomes at 8 weeks, which is when testosterone, muscle strength, and cognitive benefits become statistically significant. Take consistently — ashwagandha works cumulatively, not as a single-dose intervention.



What are the benefits of ashwagandha for stress? +
Ashwagandha is the most clinically validated natural stress relief supplement. In a 60-day RCT, it reduced serum cortisol by 27.9% and significantly improved all perceived stress scale scores vs placebo. It works by normalizing HPA axis activity — lowering excess cortisol without suppressing healthy stress responses needed for performance.



Can ashwagandha boost testosterone? +
Yes, in men with elevated stress or low-normal baseline levels. Multiple RCTs show 10–22% testosterone increases after 8–12 weeks. The mechanism is indirect: ashwagandha lowers excess cortisol, releasing suppression of the HPG axis. Men with already-healthy testosterone and low stress see smaller changes.



Does ashwagandha help with sleep? +
Yes. 3 randomized trials show ashwagandha improves sleep onset latency, total sleep time, and sleep efficiency. Benefits are largest in people with stress-related sleep difficulties. The mechanism involves cortisol reduction and GABA modulation. Take 1 capsule with your evening meal for sleep support.



Is ashwagandha safe to take every day? +
Yes — 300–1,000 mg daily is safe for continuous use. A 30-day safety trial at 1,000 mg/day found no adverse liver enzyme changes. Standard practice is 8–12 weeks of daily use. Some practitioners suggest a 2–4 week break after 3 months, though mandatory cycling is not clinically established.



Are there any side effects to taking ashwagandha root? +
Mild GI upset is the most common side effect — taking capsules with food eliminates this for most users. Rare liver enzyme elevation has been reported at very high doses. Avoid during pregnancy. Ashwagandha may lower blood sugar and enhance thyroid hormone production — consult your physician if you take related medications.



Can ashwagandha support immune function? +
Emerging evidence suggests yes. A 96-day study showed ashwagandha increased NK cell activity, T-cell counts, and immunoglobulin levels compared to placebo. Withanolides appear to modulate both innate and adaptive immune responses. This is a secondary benefit compared to its well-established stress and sleep effects.



Can I take ashwagandha during pregnancy or breastfeeding? +
No — ashwagandha is contraindicated during pregnancy. Traditional Ayurvedic texts classify it as an abortifacient at high doses, and modern caution supports avoiding it entirely during pregnancy. Insufficient safety data exists for breastfeeding. Consult your physician before taking any supplement while pregnant or nursing.



Do you offer ashwagandha in another form? +
Yes. Remedy's Nutrition also offers an Ashwagandha Tincture — a liquid ashwagandha root extract for faster absorption. The tincture is alcohol-based, 2 fl oz, with no fillers. A good option if you prefer liquid supplementation or need a faster onset.






Related Reading


How much ashwagandha should you take?
Ashwagandha benefits: what the evidence shows
Ashwagandha side effects to know
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