Yohimbe 1000 mg 60 Vegan Capsules

What Is Yohimbe Bark?
Yohimbe (Pausinystalia yohimbe) is a tall evergreen tree native to West and Central Africa, where the inner bark has been used for over 300 years as a traditional aphrodisiac and stamina tonic. Modern phytochemistry credits its effects to a single class of indole alkaloids — the most active being yohimbine — that selectively block alpha-2 adrenergic receptors. This blockade increases noradrenaline release, opens blood vessels in genital and adipose tissue, and pushes the body into a mild state of sympathetic activation. Clinical trials tested isolated yohimbine, not whole bark, and the yohimbine content of bark supplements varies widely, so a 1,000 mg bark capsule is not an equivalent dose.

Benefit Area
Key Clinical Finding
Dose Used in Trial

Erectile Dysfunction
Odds ratio 3.85 for improvement vs placebo across 7 small trials of isolated yohimbine (1998 Ernst and Pittler meta-analysis)[2]Yohimbine for ED Meta-Analysis — J Urol View source

15 to 30 mg yohimbine daily for 8 to 10 weeks

Psychogenic ED
62% improved vs 16% on placebo in the first phase of a 48-man trial; 46% responded overall (Reid 1987)
Isolated yohimbine, 10-week trial

Stubborn Fat Loss
2.2% extra body fat reduction vs placebo in lean elite athletes over 21 days
20 mg yohimbine daily, fasted training (Ostojic 2006)

Adipose Lipolysis
Free fatty acid release increased 1.5 to 2.0 fold from alpha-2-rich fat depots
0.2 mg/kg single dose, fasted state

Workout Energy
Subjective focus, drive, and time-to-fatigue improved 18 to 24% vs placebo
5 to 10 mg pre-workout

Female Sexual Arousal
Modest improvement in 2 small SSRI-induced anorgasmia trials at 5.4 to 16.2 mg
5.4 to 16.2 mg yohimbine daily

Safety Profile
Adverse event rate 7 to 12% across pooled trials; mostly mild jitteriness and BP rise under 10 mmHg
15 to 30 mg yohimbine daily

Selective alpha-2 adrenergic blockade is yohimbine's main mechanism[1]Yohimbine Clinical Review — PubMed View source

Odds ratio 3.85 for ED improvement across 7 small trials of isolated yohimbine (1998)
2.2% extra body fat loss in lean athletes over 21 days at 20 mg yohimbine daily
1.5 to 2-fold increase in free fatty acid release from alpha-2-receptor-rich stubborn fat areas
Pre-workout focus and drive improvement 18 to 24% vs placebo at 5 to 10 mg yohimbine
Compatible with fasted training, intermittent fasting, and low-carb cuts
4 to 6 week cycling protocol resets receptor sensitivity for sustained results

Isolated yohimbine is the most studied part of yohimbe for erectile dysfunction. The 1998 Ernst and Pittler meta-analysis of 7 randomized trials found it better than placebo (odds ratio 3.85), but the trials were small and tested the isolated drug, not whole bark. Mechanism runs on 3 parallel pathways:

Alpha-2 receptor blockade in penile vessels. Removing the brake on local noradrenaline release allows arterial smooth muscle to relax and corpus cavernosum to fill — the same end-state PDE5 inhibitors reach by a different route.

Central sympathetic boost. Yohimbine raises noradrenaline output in the brainstem, which increases libido, drive, and sexual interest within 30 to 60 minutes of dosing.

Reduced peripheral vasoconstriction. Stress and anxiety tighten genital vessels through alpha-2 tone; blocking those receptors blunts the stress-driven loss of erection during sexual activity.

The clearest signal is in psychogenic ED (stress, anxiety, performance pressure): in a 1987 trial of 48 men, 62% on yohimbine improved in the first phase versus 16% on placebo. Evidence for diabetic or vascular ED is weak, and yohimbe is not a replacement for prescription treatment; erectile problems can signal heart disease or diabetes, so see a doctor first. Bark capsules are not an equivalent dose to the trials, so follow the label and stop if blood pressure or anxiety rises.
Yohimbe for Fat Loss and Stubborn Body Fat
Stubborn fat areas — lower abdomen, lower back, thighs, glutes — are densely populated with alpha-2 adrenergic receptors. These receptors brake lipolysis in those exact depots, which is why dieters lose chest and arm fat first while the belly stays put. Yohimbine blocks the brake. The 2006 Ostojic trial in 20 lean elite soccer players gave 20 mg yohimbine daily during a fasted training cycle and produced 2.2% extra body fat reduction over 21 days vs placebo, with no significant lean mass change.
For yohimbe to work for fat loss, 4 conditions must be met:

Fasted training state. Insulin blunts yohimbine's lipolytic effect; the strongest effect is 8 to 14 hours after the last meal, typically morning fasted cardio.

Already lean baseline. Yohimbine works best below about 15% body fat in men and 22% in women, where alpha-2 receptors dominate. At higher body fat, beta-receptor agonists like caffeine produce larger results.

30 to 45 minutes of low to moderate intensity cardio. Long-duration steady-state work uses fat as fuel; sprint work uses glycogen. Match training to the mechanism.

4 to 6 week cycle. Receptors adapt within 2 to 3 months of daily use, reducing the lipolytic edge. Cycle 4 to 6 weeks on, 2 weeks off.

Yohimbe is not a stand-alone fat burner. Treat it as a finishing tool for the last 5 to 10 lb of stubborn fat after diet, training, and sleep are already dialed in.
Yohimbe whole bark and yohimbine HCL are not the same product. Whole bark contains yohimbine plus related alkaloids such as corynanthine and rauwolscine, and the amount varies a lot between products: a 2016 analysis of 49 US supplements found 0 to 12.1 mg of yohimbine per serving, and only 22% of labels stated an amount. Yohimbine HCL is the isolated salt at exact milligram strength, typically 2.5 to 5 mg per capsule.
Three practical implications:

Predictability. Yohimbine HCL gives an exact dose; whole bark depends on the standardization spec on the label. Choose a product that states its yohimbine content and is tested for identity and purity.

Tolerability. Both forms can raise blood pressure and heart rate and trigger anxiety; start with half a capsule and check your blood pressure.

Traditional vs. clinical. Whole bark matches 300 years of West African traditional use; HCL matches the 1989 to 2006 clinical trial doses in milligram-precise form.

For most users new to yohimbe, the standardized 1,000 mg whole-bark capsule is the safer starting point.
Why Choose Remedy's Nutrition Yohimbe Capsules

What You Get
Why It Matters

Yohimbe Dosage by Goal

Goal
Daily Dose
Timing
Time to Effect

Tolerance test (week 1)
Half capsule (500 mg)
Morning, with food
Same-day BP and pulse check

Mild psychogenic ED
1 capsule (1,000 mg)
Morning, with food
4 to 8 weeks

Moderate psychogenic ED
1 capsule + 1 capsule (2,000 mg)
Morning and 6 hours later
6 to 8 weeks

Stubborn fat loss (cut phase)
1 capsule (1,000 mg)
30 minutes pre-fasted cardio
3 to 6 weeks

Pre-workout focus and drive
Half to 1 capsule (500 to 1,000 mg)
30 to 60 minutes pre-training
Same-day acute effect

Combined ED plus fat loss
1 capsule morning + 1 capsule pre-cardio
2 doses on training days only
6 to 8 weeks

Yohimbine reaches peak plasma concentration 45 to 75 minutes after an oral dose and has a half-life of 36 minutes — so timing matters more than for most herbs. For ED support, take 30 to 60 minutes before sexual activity; for fat loss, 30 minutes before fasted cardio; for general daily use, with breakfast. Never take yohimbe within 6 hours of bedtime — the noradrenergic boost reliably disrupts sleep onset and depth in 70%-plus of users.
Tolerance Testing and Cycling Protocol
Yohimbe is one of the few herbal supplements where individual tolerance varies dramatically. Some adults feel nothing on 1,000 mg; others react to 500 mg with anxiety, BP rise, or racing pulse. The mandatory protocol:

Days 1 to 7 — half capsule (500 mg) morning with food. Check resting BP and heart rate twice daily. Record any jitteriness, anxiety, headache, or sleep disruption.

Days 8 to 14 — 1 full capsule (1,000 mg) morning with food. Continue daily BP and pulse checks; if symptoms appear, drop to half a capsule or stop.

Days 15 onward — settle on the goal dose from the table above. Stay under 2 capsules (2,000 mg) total daily.

After 4 to 6 weeks of daily use, alpha-2 receptors begin to upregulate as the body adapts. To preserve effectiveness, cycle 4 to 6 weeks on, then 2 weeks completely off, then resume. Continuous use beyond 8 weeks delivers diminishing returns and increases the chance of headaches and sleep disruption.

Yohimbe is reactive. Unlike most herbal supplements, yohimbe causes meaningful blood pressure, heart rate, and anxiety responses in some users. The 6 contraindications below are absolute — these are not "be cautious" cases but "do not take" cases.

Contraindication
Why It Matters

1. Any blood pressure medication
Yohimbe raises systolic BP 5 to 10 mmHg in most users; combining with antihypertensives produces unpredictable swings. Includes ACE inhibitors, ARBs, beta-blockers, calcium blockers, and diuretics.

2. Anxiety or panic disorder
Yohimbine reliably triggers panic attacks in panic-disorder patients at doses as low as 5 mg. Generalized anxiety, social anxiety, and PTSD are also high-risk. Avoid completely.

3. Heart disease, arrhythmia, or angina
Increased noradrenaline output raises cardiac oxygen demand and may trigger arrhythmia in vulnerable hearts. Includes coronary artery disease, atrial fibrillation, and prior heart attack.

4. SSRIs, MAOIs, or tricyclic antidepressants
Stacking yohimbine on serotonergic or noradrenergic antidepressants risks serotonin syndrome and hypertensive crisis. The MAOI combination is potentially fatal — a hard stop.

5. Pregnancy and breastfeeding
Yohimbine crosses the placenta and may affect fetal heart rate and uterine tone. Animal studies show developmental risk. Avoid through pregnancy and lactation.

6. Kidney or liver disease
Yohimbine clears via hepatic CYP2D6 metabolism and renal excretion; impaired clearance produces dangerous plasma levels. Includes chronic kidney disease stage 3-plus and any active liver disease.

Adults under 18 and over 65 should also avoid yohimbe regardless of the 6 conditions above — neither group has been studied in randomized trials, and both have higher rates of underlying cardiovascular conditions that may not be diagnosed yet.
Side Effects and Drug Interactions

Consideration
Details

If any of the following appear during a tolerance week, stop and reassess: resting BP rise over 15 mmHg systolic, resting heart rate over 100 bpm, persistent anxiety lasting beyond 6 hours, panic attack symptoms, chest pain, or severe headache. Mild jitteriness or sleep disruption above 6 pm dosing usually resolves with timing adjustment alone.
Frequently Asked Questions

What does yohimbe do? +
Yohimbe blocks alpha-2 adrenergic receptors, raising noradrenaline output and opening blood vessels in genital tissue and stubborn fat depots. The 3 main use cases are erectile dysfunction (odds ratio 3.85 across 7 small trials of isolated yohimbine), stubborn fat loss during cuts (2.2% extra body fat reduction in 21 days at 20 mg yohimbine), and pre-workout focus and drive. Standard dose is 1 capsule (1,000 mg whole bark) daily.

How long does it take yohimbe to work for ED? +
Effects on alertness can show up within 30 to 60 minutes of a single dose. In trials of isolated yohimbine, erectile improvement built over several weeks; a 1987 trial ran 10 weeks. Results are less certain for whole bark, so reassess with your doctor after 4 to 8 weeks.

Is yohimbe safe? +
Yohimbe carries more risk than most herbs. Do not use it if you have any of these 6 conditions: any BP medication, anxiety or panic disorder, heart disease, SSRI/MAOI/TCA antidepressants, pregnancy or breastfeeding, and kidney or liver disease. Adverse event rate is 7 to 12% in trials, mostly mild jitteriness and BP rise under 10 mmHg. Always start with a half capsule (500 mg) for 7 days to test tolerance.

Can yohimbe really burn stubborn fat? +
Yes, modestly, in the right context. The 2006 Ostojic trial in 20 lean elite athletes showed 2.2% extra body fat loss over 21 days at 20 mg yohimbine daily during fasted training. Effect requires 4 conditions: fasted state, baseline body fat under 15% in men or 22% in women, 30 to 45 minutes of moderate cardio, and a 4 to 6 week cycle. Yohimbe is a finisher, not a stand-alone fat burner.

What is the difference between yohimbe and yohimbine? +
Yohimbe is the whole bark; yohimbine is its main active alkaloid. Bark content varies widely: a 2016 analysis of 49 US supplements found 0 to 12.1 mg of yohimbine per serving, and only 22% of labels stated an amount. Yohimbine HCL capsules deliver an exact 2.5 to 5 mg each. Neither form is gentle on blood pressure, so start low and follow the label.

How much yohimbe should I take? +
Start with a half capsule (500 mg) for 7 days as a tolerance test. Then 1 capsule (1,000 mg) morning with food for ED, fat loss, or general daily use. For combined ED plus fat loss goals, 2 capsules split (1 morning, 1 pre-cardio) on training days only. Never exceed 2 capsules (2,000 mg) daily. Cycle 4 to 6 weeks on, 2 weeks off.

When should I take yohimbe? +
Morning is the standard timing — yohimbine has a 36-minute half-life and peak plasma at 45 to 75 minutes after a dose. For ED, take 30 to 60 minutes before sexual activity. For fat loss, 30 minutes before fasted cardio. For pre-workout focus, 30 to 60 minutes before training. Never within 6 hours of bedtime — sleep disruption affects 70%-plus of users with evening dosing.

Can I take yohimbe with caffeine or pre-workout? +
Cap caffeine at 100 mg on yohimbe days. Caffeine is a beta-receptor stimulator and yohimbine is an alpha-2 blocker — together they increase heart rate, BP, and jitteriness in an additive way. A typical pre-workout drink with 200 to 300 mg caffeine plus yohimbe is too aggressive for most users. Pick one stimulant per workout, not both at full dose.

Does yohimbe raise blood pressure? +
Yes, modestly. Most users see a 5 to 10 mmHg systolic rise within 60 to 90 minutes of a 1,000 mg dose. The effect is largest on the first dose and fades with daily use as the body adapts. If your resting BP is over 140 / 90, or you take any BP medication, do not use yohimbe. Track home cuff readings for the first 14 days of any new yohimbe protocol.

Can women take yohimbe? +
Yes, but evidence is thinner than in men. 2 small trials at 5.4 to 16.2 mg yohimbine daily showed modest improvement in SSRI-induced sexual side effects in women. For fat loss, the same alpha-2 receptor mechanism applies — and women have higher alpha-2 density in lower-body fat depots, which may favor yohimbe for stubborn thigh and glute fat at low body fat percentages. Avoid completely during pregnancy and breastfeeding.

How long does yohimbe stay in your system? +
Yohimbine has a 36-minute plasma half-life — about 90% is cleared within 4 hours of a dose. The functional alpha-2 blockade and noradrenergic boost last 4 to 6 hours, which is why morning dosing avoids sleep impact. Subjective drive and focus typically fade by 5 hours post-dose. Any noticeable jitteriness lasting beyond 6 hours suggests either dose too high or slow CYP2D6 metabolism.

Can I take yohimbe with PDE5 drugs like sildenafil? +
No documented dangerous interaction at standard doses, but always coordinate with the prescribing doctor. The 2 work through different pathways — yohimbe through alpha-2 blockade and central drive, PDE5 inhibitors through nitric oxide preservation in the corpus cavernosum. Some clinicians use yohimbine 5.4 mg with low-dose sildenafil for partial PDE5 responders. Do not combine without medical supervision.

What makes Remedy's Yohimbe Capsules different? +
Remedy's Yohimbe uses 1,000 mg whole-bark standardized at 6% per capsule — broad alkaloid coverage including alpha-yohimbine and corynanthine, not just isolated yohimbine HCL. Vegan capsule shell, no fillers, no binders, no flow agents. Manufactured in a USA cGMP facility, lab tested per batch for heavy metals, microbial contaminants, and identity. The 60-capsule bottle covers 1 standard 4 to 6 week cycle at 1 capsule daily.

Want to go deeper on a specific use case? Browse our yohimbe knowledge hub:

Yohimbe Benefits: What the Research Shows — clinical evidence breakdown across 7 RCTs and 419 men

Yohimbe for Erectile Dysfunction and Libido — mechanism, dose, and response rates by ED type

Yohimbe for Fat Loss and Pre-Workout — fasted cardio protocol and stubborn fat targeting

Yohimbe vs. Yohimbine HCL: What Is the Difference — whole bark vs. isolated alkaloid

Yohimbe Side Effects and Drug Interactions — 6 contraindications and what to monitor