Itis Be Gone™ 1000 mg, 60 Vegan Capsules

What Is Itis-Begone?
Itis-Begone is a multi-herb anti-inflammatory formula delivering 1,000 mg per vegan capsule across a curated blend of curcumin, boswellia, quercetin, ginger, and complementary herbs with documented mechanisms in joint inflammation, chronic systemic inflammation, and acute musculoskeletal pain. Each ingredient is included at evidence-aligned amounts based on published clinical research, not just traditional use. Remedy's Nutrition manufactures Itis-Begone in the USA in vegan capsules — no fillers, no artificial colors, no animal-derived ingredients.

Supplement Facts

Amount Per Serving
Amount
% Daily Value

Itis Be Gone™ Proprietary Formula — 1000 mg

Cat's Claw

†

Turmeric

†

Ginger Root

†

Feverfew

†

Holy Basil

†

Boswellia

†

White Willow Bark

†

Oregon Grape Root

†

Birch

†

Pau d'Arco

†

Juniper Berry

†

Oregano

†

† Daily Value not established.
Made in the USA.

The formula targets 4 distinct inflammatory pathways: NF-kB blockade (curcumin), 5-LOX inhibition (boswellic acids), mast cell stabilization (quercetin), and COX-2 plus 5-LOX dual action (gingerols). Designed for daily use during joint flares, seasonal inflammation, or 8–12 week protocols for chronic low-grade systemic inflammation. For the full evidence-backed anti-inflammatory protocol, see our complete anti-inflammatory supplements guide.
Each Itis-Begone ingredient has independent clinical or mechanistic research supporting its role in inflammation. The strongest evidence concentrates on knee osteoarthritis pain, rheumatoid arthritis adjunct support, and chronic systemic inflammation reduction — areas with published RCTs or meta-analyses. See our breakdown of the herbal evidence in the anti-inflammatory herbs side-by-side.

Ingredient
Mechanism
Research Signal

Curcumin (95%)
NF-kB pathway blockade
2014 RCT matched ibuprofen 1200 mg in 367 knee OA patients[1]Curcumin vs Ibuprofen Knee OA RCT (2014) View source

Boswellia (AKBA)
5-LOX inhibition
2008 5-Loxin trial showed 32% knee OA pain reduction[2]5-Loxin Boswellia OA RCT (2008) View source

Quercetin
Mast cell stabilizer; antioxidant
2016 anti-allergic immune review[3]Quercetin Anti-Allergic Immune Response (2016) View source

Ginger
COX-2 + 5-LOX dual action
2024 critical review of anti-inflammatory mechanism[4]Ginger Anti-Inflammatory Critical Review (2024) View source

Curcumin meta-analysis
Clinical pain reduction
2016 meta of 8 RCTs in 606 OA patients[5]Curcumin for Joint Arthritis Meta-Analysis (2016) View source

Active Herbs in Itis-Begone
The Itis-Begone formula combines 5 evidence-aligned anti-inflammatory ingredients in a single daily capsule rather than requiring stacking individual supplements. Each is selected for a distinct mechanism: NF-kB blockade, 5-LOX inhibition, mast cell stabilization, COX-2 inhibition, and proteolytic enzyme action.

Curcumin 95% — The active turmeric compound, blocking NF-kB transcription

Boswellia (AKBA-standardized) — 5-LOX inhibitor for the leukotriene pathway

Quercetin — Flavonoid stabilizing mast cells and reducing histamine release

Ginger Extract — Gingerols targeting both COX-2 and 5-LOX pathways

Piperine (black pepper extract) — Enhances curcumin bioavailability up to 2000%

Compare ingredient profiles in our deep dive on best joint anti-inflammatory supplements for context on how each herb fits into joint-specific routines.
Itis-Begone targets inflammation from 4 angles simultaneously. Curcumin blocks NF-kB transcription, reducing production of TNF-alpha, IL-6, and IL-1-beta inflammatory cytokines. Boswellic acids inhibit 5-lipoxygenase, blocking leukotriene production in the parallel arachidonic acid branch that NSAIDs do not touch. Quercetin stabilizes mast cells, reducing histamine and leukotriene release at the cellular level. Ginger gingerols hit both COX-2 and 5-LOX pathways for hybrid mechanism coverage.

Mechanism
What It Does
Clinical Relevance

NF-kB pathway blockade
Curcumin blocks transcription of inflammatory cytokines
Reduces TNF-alpha, IL-6 across many trial settings

5-LOX inhibition
Boswellic acids block leukotriene production
Covers the inflammatory branch NSAIDs do not touch

Mast cell stabilization
Quercetin reduces histamine and leukotriene release
Calms allergic and histamine-driven inflammation

COX-2 + 5-LOX hybrid
Gingerols inhibit both pathways at once
Faster onset relief for acute inflammatory pain

Enhanced bioavailability
Piperine boosts curcumin absorption ~2000%
Maintains therapeutic plasma curcumin levels[6]Piperine and Curcumin Bioavailability (1998) View source

Itis-Begone for Joint Pain and Arthritis
For knee, hip, and hand osteoarthritis, the curcumin + boswellia combination delivered in Itis-Begone matches the most evidence-aligned natural anti-inflammatory stack in published trials. The 2014 Kuptniratsaikul trial demonstrated curcumin 1500 mg/day matched ibuprofen 1200 mg/day for knee OA pain in 367 patients with fewer GI side effects.
For rheumatoid arthritis (autoimmune joint inflammation), Itis-Begone supports management alongside — not replacing — prescribed disease-modifying drugs (methotrexate, biologics). Pair with omega-3 at 2–3 g/day EPA+DHA for additional autoimmune-specific anti-inflammatory load. For specific arthritis context, see our natural NSAID alternatives walkthrough.
Daily Inflammation Maintenance
For chronic low-grade systemic inflammation (elevated hs-CRP above 3 mg/L), Itis-Begone provides daily anti-inflammatory load layered on top of dietary changes. Mediterranean dietary pattern reduces CRP 20–30% alone — supplements add 10–15% on top with effect appearing at 8–12 weeks. For the dietary baseline, see our 12 evidence-backed anti-inflammatory foods guide.
For acute flares, single 2-capsule doses with food provide rapid mechanism coverage. For chronic background, 2 capsules daily long-term is the supported pattern across the trials covered above.
Itis-Begone Dosage
Standard adult dose: 2 capsules daily with food. Take with 240 ml of water for optimal absorption. May be split into 1 capsule AM and 1 capsule PM for steady 24-hour coverage. Maximum 4 capsules daily for short courses (1–2 weeks) during acute joint flares.

Goal
Daily Dose
Timing
Duration

Daily joint maintenance
2 capsules
With breakfast or largest meal
Ongoing

Chronic inflammation 12-week reset
2 capsules
1 AM, 1 PM
12 weeks then reassess

Acute joint flare
4 capsules
2 AM, 2 PM with meals
1–2 weeks acute, then taper

Pre-event load (athletic)
2 capsules
2 hours before activity
As needed

Maintenance
1–2 capsules
With largest meal
Ongoing

Take Itis-Begone with food containing healthy fat to optimize curcumin and boswellic acid absorption. Avoid pairing with very hot beverages (above 65°C / 150°F) which can denature heat-sensitive components. For dosing across goals beyond joints, our 7-day inflammation reduction protocol covers stacking with diet and sleep.
Why Choose Remedy's Itis-Begone

What You Get
Why It Matters

1,000 mg multi-herb blend per capsule
Single capsule covers 4 inflammatory pathways instead of stacking 4 separate supplements

Curcumin standardized to 95% curcuminoids
Therapeutic-grade matched to the trial dose used in head-to-head ibuprofen comparison

Boswellia AKBA-standardized
The bioactive boswellic acid form with the strongest 5-LOX inhibition data

USA-manufactured in GMP-certified facility
Quality control, batch testing, and FDA-compliant labeling for every lot

Vegan capsule (no gelatin)
Plant-cellulose shell suitable for vegetarian and vegan customers

No fillers, no artificial colors
Active herbal content only — no rice flour, no magnesium stearate fillers

60 capsules per bottle
30-day supply at 2 capsules daily, or 60-day at 1 capsule maintenance

3rd-party tested for purity
Certified free of heavy metals, microbial contamination, and pesticide residues

Safety, Interactions, and Cautions
Itis-Begone has a strong safety profile when used as directed, but several specific interactions and cautions apply. Always discuss new supplements with your healthcare provider, particularly during pregnancy, with prescription medications, or before surgery. For broader female-specific safety guidance, see our anti-inflammatory protocol for women.

Drug class / Condition
Interaction
Action

Warfarin (Coumadin)
Curcumin, boswellia, ginger all add anticoagulation
Avoid or monitor INR closely with prescriber

DOACs (apixaban, rivaroxaban)
Compounded bleeding risk
Discuss with prescriber before starting

Antiplatelets (clopidogrel, aspirin)
Curcumin and quercetin add platelet inhibition
Discuss with prescriber; monitor for bruising

Pre-surgery (within 2 weeks)
Anticoagulant effect of multiple herbs
Discontinue 2 weeks before any scheduled surgery

Pregnancy
High-dose curcumin and boswellia lack pregnancy safety data
Avoid during pregnancy — confirm with OB

Methotrexate / DMARDs
Curcumin may modestly raise plasma methotrexate
Rheumatologist clearance before stacking

Liver disease (active)
Rare turmeric-induced hepatotoxicity in HLA-B*35:01 carriers[7]Turmeric (Curcuma longa) — LiverTox (NIH NIDDK) View source

Baseline LFTs; avoid with active hepatitis

Children under 12
Adult dosing not appropriate
Use only under pediatrician guidance

Stop Itis-Begone and call your doctor immediately if you experience:

Unusual bleeding, bruising, or prolonged bleeding from minor cuts
Severe allergic reaction (hives, swelling, breathing difficulty)
Right upper quadrant abdominal pain or jaundice (rare hepatotoxicity)
Severe stomach pain or persistent nausea
Sinus symptoms worsening with fever above 102°F for 3+ days

Beyond the safety table above, several common medication classes interact with components of Itis-Begone. Confirm before starting if you take any of the following.[8]Warfarin Herbal Supplement Interactions (2020) View source

Medication Class
Mechanism of Concern
What to Do

Anticoagulants (warfarin, heparin)
Curcumin/boswellia/ginger potentiate bleeding
Avoid or close INR monitoring

Direct oral anticoagulants (DOACs)
Theoretical additive bleeding risk
Discuss with prescriber

NSAIDs (ibuprofen, naproxen)
Curcumin may amplify GI effects
Use lowest effective NSAID dose with food

ACE inhibitors / ARBs
Quercetin may enhance hypotensive effect
Monitor BP, especially first 2 weeks

Tamoxifen / endocrine cancer therapy
Quercetin and curcumin CYP3A4 interactions
Oncologist clearance required

Diabetes medications
Curcumin and ginger may enhance glucose lowering
Monitor glucose, especially first 2 weeks

Itis-Begone vs OTC NSAIDs
Over-the-counter NSAIDs like ibuprofen and naproxen work fast but carry trade-offs for chronic use: GI bleeding risk (especially over age 60), cardiovascular event risk, and kidney impairment in CKD. Itis-Begone covers different and complementary inflammatory pathways with a different safety profile. For comparison context, see our chronic inflammation warning signs walkthrough.

Feature
Itis-Begone
Ibuprofen
Naproxen

Speed of relief
2–4 weeks subjective
30–60 minutes
1–2 hours

Use duration
Daily long-term
10 days max chronic
10 days max chronic

GI bleeding risk
Low at standard dose
Significant chronic
Higher than ibuprofen

Kidney impact
Minimal
Reduces renal blood flow
Reduces renal blood flow

Pathways covered
NF-kB + 5-LOX + COX-2 + mast cell
COX-1, COX-2
COX-1, COX-2

Anticoagulants, methotrexate
Many, including aspirin
Many, similar to ibuprofen

Pregnancy use
Not recommended (no data)
Avoid 3rd trimester
Avoid 3rd trimester

Pregnancy and Pediatric Use
Itis-Begone is not recommended for pregnant or breastfeeding women without obstetric clearance. Individual ingredients (high-dose curcumin, boswellia) lack robust combined-formula pregnancy safety data — this is not a statement of harm but reflects insufficient research in pregnant populations. Mechanical and dietary anti-inflammatory methods covered in our Mediterranean inflammation diet protocol are the recommended path during pregnancy.
For children: Itis-Begone adult dosing is not appropriate for children under 12. Use only under pediatrician guidance. The Mediterranean diet plus daily turmeric in cooking provides safer pediatric anti-inflammatory exposure.
Frequently Asked Questions

How quickly does Itis-Begone work? +
Most users report subjective improvement in 2–4 weeks of daily use at 2 capsules per day. Full anti-inflammatory effect typically emerges by week 8–12. For acute joint flares, expect noticeable changes within the first 7–10 days at the 4-capsule short-course dose. Pair with Mediterranean dietary pattern for the fastest visible improvement — diet shifts CRP 20–30% on its own.

What is the difference between Itis-Begone and ibuprofen? +
Ibuprofen is an OTC NSAID that blocks COX-1 and COX-2 enzymes within 30–60 minutes for fast pain relief but carries GI, cardiovascular, and renal risk on chronic use. Itis-Begone is a daily multi-herb supplement covering 4 inflammatory pathways (NF-kB, 5-LOX, COX-2, mast cell) over 2–4 weeks. Ibuprofen wins on speed; Itis-Begone wins on chronic-use safety.

Can I take Itis-Begone with my daily ibuprofen? +
Discuss with your prescriber. For short periods, generally yes — the curcumin in Itis-Begone may modestly raise GI side effect risk when combined with chronic ibuprofen. The cleaner approach: use Itis-Begone to gradually reduce ibuprofen needs over 8–12 weeks. Some users taper ibuprofen by 50% at week 8 and discontinue by week 12 with their doctor's input.

Is Itis-Begone safe for daily long-term use? +
Yes for most adults. Curcumin, boswellia, quercetin, and ginger each have human safety data for use up to 12 months at recommended doses. Take 2-week breaks every 3 months for cyclical use, or use during flare seasons (cold weather, increased physical demand). Discuss longer-term use with your doctor if you have chronic conditions or take prescription medications.

Can I take Itis-Begone during a chemo or radiation treatment? +
Always check with your oncologist first. Curcumin and quercetin have CYP3A4 interactions that may affect tamoxifen, methotrexate, doxorubicin, and other chemo drugs. Antioxidant activity is theoretically concerning during active radiation treatment. For most oncology patients, Itis-Begone is paused during active treatment and resumed in survivorship under your oncologist's guidance.

Does Itis-Begone contain any allergens? +
Itis-Begone is free of the 9 major FDA-defined allergens (milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy, sesame). Vegan capsule shell is plant cellulose — no gelatin, no animal-derived ingredients. The piperine ingredient comes from black pepper, so pepper allergy sufferers should choose a piperine-free curcumin product instead. Ginger root and turmeric (zingiberaceae family) can rarely cause cross-sensitivity.

Why curcumin plus boswellia plus quercetin together? +
Each targets a different inflammatory pathway: curcumin blocks NF-kB transcription, boswellia inhibits 5-lipoxygenase, quercetin stabilizes mast cells, and ginger hits COX-2 plus 5-LOX. The 4-ingredient combination covers OA, RA, allergic inflammation, and acute pain mechanisms in a single capsule, replacing 4 separate supplements at standardized therapeutic doses. Multi-pathway coverage outperforms single-ingredient stacks for daily background.

Can I take Itis-Begone if I take a daily aspirin? +
Discuss with your doctor first. Low-dose aspirin (81 mg) combined with curcumin, boswellia, and ginger may slightly increase bleeding risk through compounded anticoagulant effects. For healthy adults on cardiovascular-protective aspirin, the additional risk is small but real. Your prescriber may recommend a 2-week trial with monitoring or reduced Itis-Begone dose to start, or recommend testing with pulled blood timing.

How does Itis-Begone compare to single curcumin products? +
Single curcumin at 1000–1500 mg with piperine is the gold standard for OA-specific protocols matched to the published Kuptniratsaikul ibuprofen-comparison RCT. Itis-Begone covers broader inflammation by adding boswellia (5-LOX), quercetin (mast cell), and ginger (COX-2). For pure knee OA: single curcumin. For chronic systemic inflammation, allergic component, or multiple joint sites: Itis-Begone covers wider pathways.

When should I see a doctor instead of using Itis-Begone? +
See a doctor for new joint swelling with fever, morning stiffness over 60 minutes for 6+ weeks, unexplained weight loss above 5%, night sweats with joint pain, joint deformity, hs-CRP above 10 mg/L without obvious infection, or new neurological symptoms. These flag rheumatoid arthritis, lupus, polymyalgia rheumatica, or other conditions needing medical workup. Itis-Begone supports recovery but never substitutes for medical evaluation.

Can Itis-Begone help with rheumatoid arthritis? +
Yes as adjunct support — never as replacement for disease-modifying drugs. The boswellia and curcumin combination has the strongest natural anti-inflammatory data for RA management alongside methotrexate or biologics. Pair with omega-3 at 2.7 g/day EPA+DHA (separate fish oil supplement). Always coordinate with your rheumatologist before adding herbal supplements to an RA medication regimen.

How should I store Itis-Begone? +
Store in a cool, dry place below 25°C (77°F), away from direct sunlight and humidity. Avoid the bathroom or near heat sources. Keep the bottle tightly closed between uses. Curcumin and gingerols are heat-sensitive — do not store above 30°C for long. Discard 6 months after opening or by the expiration date on the label, whichever comes first. Keep out of reach of children.

Does Itis-Begone interact with other Remedy's herbal blends? +
Itis-Begone can be safely combined with most Remedy's herbal blends. Avoid stacking 2 different curcumin or boswellia products at full doses without calculating total daily intake. For chronic inflammation, the most evidence-aligned stack is Itis-Begone with Mediterranean diet, omega-3 fish oil, and Lymph Cleanse for systemic support. Avoid stacking multiple high-dose anticoagulant herbal blends in patients on warfarin or DOACs.

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